Ko nga Ginsenosides he momo hua taiao triterpenoid glycosylated e kitea ana i roto i te ginseng Panax. Ko nga Ginsenosides he huanga antioxidant, anti-inflammatory, anti-fibrosis and anti{3}}tumor effects. I whakarāpopotohia te mahi rongoora me te tikanga o te ginsenosides ki te fibrosis okana hei whakarato i te kaupapa ariā mo te rangahau mo te -fibrosis o enei pūhui.
I te mutunga o te rau tau 1800 i whakaarohia tuatahitia te kupu rongoa "fibrosis". He mate mau tonu e tohuhia ana e te kino, te nui rawa ranei o te kohinga o nga pūmua matrix extracellular (ECM) i roto i nga kopa me nga whekau i te wa e whakautu ana ki te whara me te whakatikatika. Ko te ECM ehara i te mea he scaffold anake e whakapumau ana i te kiko, engari e kaha whakatairanga ana ano hoki i te whakapumautanga i roto i te kiko -te taiao me te whakaora patunga ma te whakakotahi i nga cytokine maha me nga mea tupu. I etahi wa ka whai hua te fibrosis; heoi, i te nuinga o nga mate he kino te fibrosis. Ko nga raraunga e whakaatu ana ko te 45% o nga mate e pa ana ki te -mate e pa ana ki te fibrosis. Tata ki nga whekau katoa ka pa te fibrosis, ina koa nga whekau nui penei i te ate, te huhu, te ngakau me te whatukuhu. Ko etahi o nga mate mau tonu, penei i te mate huka, te takawhita, te mate ate mate mate me te mate mate autoimmune, te ngoikore o te ngakau, te cardiomyopathy, te mate pukupuku idiopathic, te scleroderma me te mate pukupuku, he hononga tata ki te fibrosis. He whenua nui a Haina ki te mate ate ate, koinei te take nui o te mate ate fibrosis. Ko te fibrosis ate he tukanga whakaora patunga ka taea te whakahoki e whai ana ki te pupuri i te pono o te okana, a he tukanga pathological matua i te timatanga o te cirrhosis. Ka puta te Cirrhosis ki te mate pukupuku ate kaore he whakawhitinga ate. Ko nga raraunga whai take e whakaatu ana ko te mate a-tau o te mate hepatitis B mau tonu ki te cirrhosis he 2%-10%. Kei te raru a Haina ki te aukati me te maimoatanga o te cirrhosis ate, a ka tata tonu ka pa ki te raru o te maimoatanga fibrosis pulmonary. I tenei wa, kei te whakahaerehia te pakarutanga COVID-19 i Haina, engari he raru ohorere te maimoatanga whai muri. Ko te fibrosis pulmonary he huringa pathological matua i roto i nga turoro i roto i te waahanga whakaora o COVID-19. Mena ka taea te whakakore i te etiology me te whakahaere wawe i te wawaotanga, ka nui ake te tupono ki te whakahoki mai i te fibrosis. Ko te fibrosis o te tinana ka whakaheke i te oranga o nga turoro, ka pa he kino ki te oranga me te hauora o te tangata. Na reira, he mea nui ki te whakamarama i te pathogenesis o te fibrosis me te whakawhanake me te whakamahi i nga raau taero anti-fibrosis whai hua.
E rima nga wahanga o te fibrosis: te whara okana, te whakahohenga o te pūtau effector, te whakakaha o te hanga ECM, te whakakorikori o te kiko hono me te whakahou i te kiko. Ko te pakaru o te kopa he take nui mo te fibrosis. Na te piki haere o te mate, ka puta te ahua o te kiko kino, ka whakangaro i te hanganga o nga whekau ahupūngao, i te mutunga ka paheke te okana me te kore. Kua maha ake nga rangahau mo nga tauira fibrosis kararehe kua whakapumau ka taea te whakahoki mai i etahi o nga mate fibrotic i etahi wa.
Kua kitea e te rangahau nui nga tikanga uaua o te fibrosis, tae atu ki nga momo momo pūtau, nga take, nga hongere tohu me nga ira. I roto i era, ko te tukunga ECM, -te ahua o te Muscle Actin ( -SMA), te whakahuri i te tauwehe tipu - 1 (whakawhitinga tipu - 1), TGF- 1 (TGF- 1) /Ko te ara tohu tohu Smads he whainga mo te fibrosis okana. I tua atu i te tikanga whanui o te fibrosis, he rereke te urupare o ia okana ki te whara, tae atu ki te aukati i te urupare inflammatory, te whakakore i te whakawhitinga tomesenchymal epithelial, EMT), te whakapai ake i te urupare oxidative, te whakakore i te hanga collagen, te whakahaere i te whakaaturanga cytokine me etahi atu waahanga e whakaatu ana i nga ahuatanga fibrosis ahurei. Ko te taunekeneke o enei tikanga whai hua ka arahi ki te kohinga nui o te ECM, ka mutu ka whakakapi me te whakangaro i nga hanganga okana tinana.
I tenei wa, ko nga raau taero anti-liver fibrosis e aro ana ki nga whaainga ko te obeticholicacid, FXR agonist, peroxisome proliferator activated receptor /δ, PPAR /δ dual agonist Elafibranor (GFT505), cyclo-Oxygenase (CYcoperoxygenase) me te TGF{3}} kua whakaaetia i tenei wa. Ahakoa kua paahi a Fuzheng Huayu capsule i nga whakamatautau haumanu i te wahanga III i te United States, ko ona waahanga uaua me te whaainga marama kaore ano kia whakaaetia hei rongoa haumanu mo te -mate fibrosis ate. I tenei wa, ko te pirfenidone (Pirfenidone) anake me te Nidanib (Ninte ‐danib / BIBF1120) kua whakaaetia mo te tono haumanu mo te maimoatanga o te fibrosis pulmonary idiopathic. Ko te whainga o te pirfenidone ko te mahi i te mahi anti-pulmonary fibrosis ma te whakaheke-whakahaere i te TGF- me te whakaputanga o te collagen. Ko te Nidanib he aukati iti ngota tyrosine kinase e mahi ana ki te fibrosis pulmonary ma te aukati i nga huarahi tohu e uru ana ki te haere whakamua o te fibrosis pulmonary. Ko te tarukino anti-cardiac fibrosis Edaravone e whakaiti ana i te myocardial fibrosis ma te heke-whakahaere i te TGF- 1/SMad2/3, i tenei wa he antioxidant kua whakaaetia me te kaipatu tuwhena kore utu. Kua kitea e nga whakamatautau in vitro he mahi anti-TGF - a Tranilast ka taea te whakaiti i te whakahiato collagen o nga fibroblasts. Ahakoa he maha nga raau taero anti-renal fibrosis e aro ana ki te TGF- kua korerohia, kaore he rangahau haumanu mo te-renal fibrosis i naianei. Na reira, he hiahia tere ki te kimi i tetahi hua maori me te tino pai me te iti o te paitini.
Ko te ginseng, he ginseng o te whanau acanthopanax, he rongoa Hainamana tuku iho me te hitori neke atu i te 4000 tau. Ko nga Ginsenosides he karaehe o nga triterpenoid glycosylated i kitea i roto i te ginseng. I tenei wa, tata ki te 180 ginsenosides kua tohua mai i nga momo panax 17. Ka kitea ano te ginsenosides i roto i te ginseng Brazilian Pfaffia glomerate (Spreng)Pedersen, he amaranth. I te mea ko te tino whakauru koiora o te ginseng, he maha nga painga hauora o nga ginsenosides, tae atu ki te hypoglycemic, antioxidant, antibacterial, anti-platelet, anti-tumor me era atu. I tenei wa, kaore e taea e nga ginsenosides te whakarei ake i te punaha o te pokapū matua, engari he mea nui ano hoki ki te whakapai ake i nga oko toto, te tiaki i te punaha cardiovascular me te whakahaere i te mahi aukati.
Ko nga ginsenosides taiao ka taea te wehewehe ki nga waahanga e whai ake nei: (1) Oleanolic acid (oleanane pentacyclic triterpenoid ginsenosides): Ginsenoside Ro; (2) Proto -ginsenediol (tetracyclic triterpenoid saponins momo damarane): Ginsenoside Ra1, Ra2, Ra3, Rb1, Rb2, Rb3, Rc, Rd, Rg3, Rh2, Rs1, Rs2, malonylginsenoside Rb1, Rb2, Rb2, Rb1, Rb2, Rb1 Panax quinquinide R1, 20(S) -ginsenoside Rg3, 20(R) -ginsenoside Rh2, 20(S) -ginsenoside Rh2, proto-ginsenediol, etc.; (3) Proto -ginsentriol (damarane-momo tetracyclic triterpenoid saponins) : Ginsenoside Re, Rf, Rg1, Rg2, Rh1, Rh3, Rf1, 20-glucoside ginsenoside Rf, 20(R}) {{20}Rg2) {{20}Rg2 -ginsenoside Rh1, notoginseng ginsenoside R1, pseudoginsenoside R11, Rp1, Rt1, Chikusetsusaponin ⅳ me ⅳ A, protoginseng triol, me etahi atu. He rereke nga paanga o nga momo ginsenosides rereke.
